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CGS 21680 (Hydrochloride)

CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.

Product Specifications

CAS Number

124431-80-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CGS-21680-Hydrochloride.html

Purity

99.70

Solubility

DMSO : ≥ 20 mg/mL|H2O : < 0.1 mg/mL

Smiles

O=C(O)CCC1=CC=C(CCNC2=NC3=C(N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](C(NCC)=O)O4)C(N)=N2)C=C1.Cl

Molecular Formula

C23H30ClN7O6

Molecular Weight

535.98

Precautions

H302, H315, H319, H335

References & Citations

[1]Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38 (3) :969-75.|[2]Zhang M, et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36.|[3]Melani A, et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72.|[4]Komaki S, et al. Trk and cAMP-dependent survival activity of adenosine A (2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522 (1) :21-4.|[5]Rosaria Volpini, et al. Adenosine receptor agonists: synthesis and binding affinity of 2- (aryl) alkylthioadenosine derivatives.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Acta Pharmacol Sin. 2025 May;46 (5) :1177-1189.|Cell Mol Gastroenterol Hepatol. 2025 May 21:101539.|Eur J Med Res. 2024 Aug 27;29 (1) :433.|J Cell Mol Med. 2025 Mar;29 (5) :e70458.|Nature. 2025 Nov 5.|Placenta. 2025 Nov 7;172:150-158.|Research Square Print. December 13th, 2022.|Cell Death Dis. 2020 Mar 23;11 (3) :202.|Ecotoxicol Environ Saf. 2023 Jan 1:249:114410.|Iran J Basic Med Sci. 10, Oct 2021.|J Neuroinflammation. 2022 Feb 18;19 (1) :52.|Neurochem Int. 2021 May:145:104983.|Research Square Preprint. 2021 Aug.

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