CGS 21680 (Hydrochloride)
CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.
Product Specifications
CAS Number
[124431-80-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CGS-21680-Hydrochloride.html
Purity
99.70
Solubility
DMSO : ≥ 20 mg/mL|H2O : < 0.1 mg/mL
Smiles
O=C(O)CCC1=CC=C(CCNC2=NC3=C(N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](C(NCC)=O)O4)C(N)=N2)C=C1.Cl
Molecular Formula
C23H30ClN7O6
Molecular Weight
535.98
Precautions
H302, H315, H319, H335
References & Citations
[1]Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38 (3) :969-75.|[2]Zhang M, et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36.|[3]Melani A, et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72.|[4]Komaki S, et al. Trk and cAMP-dependent survival activity of adenosine A (2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522 (1) :21-4.|[5]Rosaria Volpini, et al. Adenosine receptor agonists: synthesis and binding affinity of 2- (aryl) alkylthioadenosine derivatives.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Acta Pharmacol Sin. 2025 May;46 (5) :1177-1189.|Cell Mol Gastroenterol Hepatol. 2025 May 21:101539.|Eur J Med Res. 2024 Aug 27;29 (1) :433.|J Cell Mol Med. 2025 Mar;29 (5) :e70458.|Nature. 2025 Nov 5.|Placenta. 2025 Nov 7;172:150-158.|Research Square Print. December 13th, 2022.|Cell Death Dis. 2020 Mar 23;11 (3) :202.|Ecotoxicol Environ Saf. 2023 Jan 1:249:114410.|Iran J Basic Med Sci. 10, Oct 2021.|J Neuroinflammation. 2022 Feb 18;19 (1) :52.|Neurochem Int. 2021 May:145:104983.|Research Square Preprint. 2021 Aug.
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