FIN56
Product Specifications
UNSPSC Description
FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase[1].
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/FIN56.html
Purity
99.27
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1=CC(/C2=N\O)=C(C3=C2C=C(S(=O)(NC4CCCCC4)=O)C=C3)C=C1)(NC5CCCCC5)=O
Molecular Weight
517.66
References & Citations
[1]Kenichi Shimada, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.|[2]Michael M Gaschler, et al. FINO<sub>2</sub> initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515.|[3]Yangchun Xie, et al. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017 Aug 15;20(7):1692-1704.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103087/FIN56-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103087/FIN56-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1083162-61-1
Available Sizes
Curated Selection
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