ROCK-IN-10
ROCK-IN-10 (compound 50) is a potent ROCK inhibitor with IC50 values of 6 nM and 4 nM for ROCK1 and ROCK2, respectively. ROCK-IN-10 shows >100-fold selectivity against other kinases[1].
Product Specifications
CAS Number
[1038549-25-5]
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rock-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(NC(NCC2=CC(C(NC3=CC=C4C(CNCC4)=C3)=O)=CC=C2)=O)C=C1)N
Molecular Formula
C25H25N5O3
Molecular Weight
443.50
References & Citations
[1]Tina Morwick, et al. Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. J Med Chem. 2010 Jan 28;53 (2) :759-77.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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