ROCK-IN-10

ROCK-IN-10 (compound 50) is a potent ROCK inhibitor with IC50 values of 6 nM and 4 nM for ROCK1 and ROCK2, respectively. ROCK-IN-10 shows >100-fold selectivity against other kinases[1].

Product Specifications

CAS Number

[1038549-25-5]

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rock-in-10.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(NC(NCC2=CC(C(NC3=CC=C4C(CNCC4)=C3)=O)=CC=C2)=O)C=C1)N

Molecular Formula

C25H25N5O3

Molecular Weight

443.50

References & Citations

[1]Tina Morwick, et al. Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. J Med Chem. 2010 Jan 28;53 (2) :759-77.