Tat-beclin 1
Product Specifications
UNSPSC Description
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV)[1].
Target Antigen
Autophagy; HIV
Type
Peptides
Related Pathways
Anti-infection;Autophagy
Applications
Cancer-programmed cell death
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tat-beclin-1.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC6=CC=CC=C6)C(NCC(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC7=CC=C(C=C7)O)N
Molecular Weight
3741.10
References & Citations
[1]Sanae Shoji-Kawata, et al. Identification of a Candidate Therapeutic Autophagy-Inducing Peptide. Nature. 2013 Feb 14;494(7436):201-6.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2260/Tat-beclin-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2260/Tat-beclin-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1423821-88-8
Available Sizes
Curated Selection
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