P60-L3-VHL
P60-L3-VHL is a PROTAC-class Foxp3 degrader. P60-L3-VHL reduced cell differentiation and Foxp3 expression in activated Treg cells in vitro and had anti-tumor activity (Blue: E3 ligase ligand ; Pink: target protein ligand (HY-162946) ; Black: linker (HY-162947) ).
Product Specifications
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p60-l3-vhl.html
Purity
99.84
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)(C)C)NC(COCCOCCNC(CCCCCN2C=C(CCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N7CCC[C@H]7C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](C)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)CO)=O)=O)=O)=O)=O)N=N2)=O)=O)=O)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10
Molecular Formula
C135H189N33O27S3
Molecular Weight
2802.35
References & Citations
[1]Yang B, et al. Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129945.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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