Recombinant Human Exodus-2/CCL21
Product Specifications
Background
CCL21 is encoded by CCL21 gene that is located in Chr. 9 and shows 21-33 % identity to other CC chemokines. This chemokine contains the four conserved cysteines characteristic of β chemokines plus two additional cysteines in its unusually long carboxylterminal domain. CCL21 is highly expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. It elicits effects by binding with CCR7, having functions of T and B lymphocytes chemotaxis and inhibiting hematopoiesis.
Product Name Alternative
6Ckine, Beta-chemokine Exodus-2, SLC
Gene ID
6366
UniProt
O00585
Target
SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCK RTERSQTPKG P
Purification
> 95 % by SDS-PAGE analyses.
Endotoxin
Less than 1 EU/ug of rHuExodus-2/CCL21 as determined by LAL method.
Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 10-100 ng/ml.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 12.2 kDa, a single, non-glycosylated polypeptide chain containing 111 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 2 x PBS, pH 7.0.
Host or Source
Escherichia coli
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