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N-Acetyl-L-tyrosine (Standard)

N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine. This product is intended for research and analytical applications. N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer[1][2][3].

Product Specifications

CAS Number

537-55-3

UNSPSC

12352005

Target

Endogenous Metabolite; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/n-acetyl-l-tyrosine-standard.html

Purity

99.57

Smiles

OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC(C)=O

Molecular Formula

C11H13NO4

Molecular Weight

223.23

References & Citations

[1]Matsumura T, et al. N-acetyl-l-tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals. EMBO Rep. 2020 May 6;21 (5) :e49211.|[2]Bjelton, Lilian, et al. "N-acetyl-L-tyrosine as a source of tyrosine in intravenous nutrition an experimental study in the rat." Nutrition Research 9.5 (1989) : 555-564.|[3]Kumar R, et al. Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators. Eur J Med Chem. 2007 Apr;42 (4) :503-10.

Shipping Conditions

Room Temperature

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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