Bizelesin

Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1].

Product Specifications

CAS Number

[129655-21-6]

Product Name Alternative

NSC 615291; U-77779

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bizelesin.html

Purity

95.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC2=C(NC(C(N3C4=CC(O)=C5NC=C(C)C5=C4[C@H](CCl)C3)=O)=C2)C=C1)NC6=CC7=C(NC(C(N8C9=CC(O)=C%10NC=C(C)C%10=C9[C@H](CCl)C8)=O)=C7)C=C6

Molecular Formula

C43H36Cl2N8O5

Molecular Weight

815.70

References & Citations

[1]J M Woynarowski, et al. AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs. J Biol Chem. 2001 Nov 2;276 (44) :40555-66. |[2]J M Woynarowski, et al. Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells. Biochim Biophys Acta. 1997 Jul 17;1353 (1) :50-60.