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5-Methyl-2'-O,4'-C-methylenecytidine

5-Methyl-2'-O,4'-C-methylenecytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

Product Specifications

CAS Number

[847650-87-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others; Cancer

Assay Protocol

https://www.medchemexpress.com/5-methyl-2-o-4-c-methylenecytidine.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@@]12O[C@@H](N3C(N=C(C(C)=C3)N)=O)[C@@](OC2)([H])[C@@H]1O

Molecular Formula

C11H15N3O5

Molecular Weight

269.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3 (11) :1062-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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