(Z) -Aconitic acid

(Z) -Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z) -Aconitic acid reduces IκB-α phosphorylation. (Z) -Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A) -induced gout[1][2].

Product Specifications

CAS Number

[585-84-2]

Product Name Alternative

Cis-Aconitic acid

UNSPSC

12352211

Hazard Statement

H315, H319, H335, H350

Target

Amino Acid Decarboxylase; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/z-aconitic-acid.html

Concentration

10mM

Purity

99.28

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)/C([H])=C(C(O)=O)/CC(O)=O.

Molecular Formula

C6H6O6

Molecular Weight

174.11

Precautions

H315, H319, H335, H350

References & Citations

[1]de Oliveira DP, et al. cis-Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice. Planta Med. 2022 Oct;88 (13) :1123-1131.|[2]Endo A, et al. Cis-and tram-aconitic acids as inhibitors of glutamate decarboxylase. Hoppe-Seyler’s Z. Physiol, 1977: 1365-1368.