Fustin
Fustinis ((±) -Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±) -Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42) . Fustinis ((±) -Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42) . Fustinis ((±) -Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±) -Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1].
Product Specifications
CAS Number
[20725-03-5]
Product Name Alternative
(±) -Fustin; 3,7,3',4'-Tetrahydroxyflavanone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β; Cholinesterase (ChE) ; mAChR
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fustin.html
Purity
99.6
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
OC1=CC([C@H]2OC3=CC(O)=CC=C3C([C@@H]2O)=O)=CC=C1O
Molecular Formula
C15H12O6
Molecular Weight
288.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Jin CH, et, al. Fustin flavonoid attenuates beta-amyloid (1-42) -induced learning impairment. J Neurosci Res. 2009 Dec;87 (16) :3658-70.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE; mAChR1
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