2,2,5,7,8-Pentamethyl-6-Chromanol

2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol) . 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].

Product Specifications

CAS Number

[950-99-2]

Product Name Alternative

PMC

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Androgen Receptor; NF-κB

Type

Reference compound

Related Pathways

NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/2-2-5-7-8-pentamethyl-6-chromanol.html

Concentration

10mM

Purity

99.30

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC1=C(C)C(C)=C2C(CCC(C)(C)O2)=C1C

Molecular Formula

C14H20O2

Molecular Weight

220.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34 (2) :225-30.|[2]Hsiao G, et al., The protective effects of PMC against chronic carbon tetrachloride-induced hepatotoxicity in vivo. Biol Pharm Bull. 2001 Nov;24 (11) :1271-6.|[3]Hsiao G, et al., Antithrombotic effect of PMC, a potent alpha-tocopherol analogue on platelet plug formation in vivo. Br J Haematol. 2002 Jun;117 (3) :699-704.|[4]Hsiao G, et al., Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. Biochem Pharmacol. 2007 Mar 1;73 (5) :682-93.