ICT10336
Product Specifications
UNSPSC Description
ICT10336 is a hypoxia-responsive prodrug of ATR inhibitor, AZD6738 (HY-19323). ICT10336 is hypoxia-activated and specifically releases AZD6738 only in hypoxic conditions in vitro. This can inhibit ATR activation (T1989 and S428 phosphorylation) and subsequently abrogate HIF1a-mediated adaptation of hypoxic cancers cells, thus selectively inducing cell death in 2D and 3D cancer models. ICT10336 is a metabolic substrate of CYPOR activity.
Target Antigen
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ict10336.html
Smiles
C[C@H](COCC1)N1C2=CC(C3(S(=NC([C@H](CC(C)C)NC(OCC4=CN=C([N+]([O-])=O)N4C)=O)=O)(C)=O)CC3)=NC(C5=C6C(NC=C6)=NC=C5)=N2
Molecular Weight
708.79
References & Citations
[1]Francis M Barnieh, et al. Hypoxia-Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment-Resistant Cancer Cells. Adv Sci (Weinh). 2024 Jul 8:e2403831.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161838/ICT10336-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161838/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
10799114 3 x 1.0 µg
5730437N04Rik sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Ask
View Details