ICT10336
ICT10336 is a hypoxia-responsive prodrug of ATR inhibitor, AZD6738 (HY-19323) . ICT10336 is hypoxia-activated and specifically releases AZD6738 only in hypoxic conditions in vitro. This can inhibit ATR activation (T1989 and S428 phosphorylation) and subsequently abrogate HIF1a-mediated adaptation of hypoxic cancers cells, thus selectively inducing cell death in 2D and 3D cancer models. ICT10336 is a metabolic substrate of CYPOR activity.
Product Specifications
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ict10336.html
Smiles
C[C@H](COCC1)N1C2=CC(C3(S(=NC([C@H](CC(C)C)NC(OCC4=CN=C([N+]([O-])=O)N4C)=O)=O)(C)=O)CC3)=NC(C5=C6C(NC=C6)=NC=C5)=N2
Molecular Formula
C32H40N10O7S
Molecular Weight
708.79
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATR
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