Tenofovir
Tenofovir (GS 1278) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV) [1].
Product Specifications
CAS Number
147127-20-6
Product Name Alternative
GS 1278; PMPA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HBV; HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/tenofovir.html
Purity
99.92
Solubility
DMSO : 7.69 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 2 mg/mL (ultrasonic)
Smiles
C[C@@H](OCP(O)(O)=O)CN1C=NC2=C(N)N=CN=C12
Molecular Formula
C9H14N5O4P
Molecular Weight
287.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18 (3) .|[2]Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018.|[3]Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098.|[4]Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49 (7) :2720-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1
Available Sizes
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