TIM-098a

TIM-098a is a selective AAK1 inhibitor with an IC50 of 0.24 µM. TIM-098a has no inhibitory activity against CaMKK isoforms. TIM-098a inhibits AAK1-regulated endocytosis by suppressing AAK1 kinase activity[1].

Product Specifications

UNSPSC

12352005

Target

AAK1

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tim-098a.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC2=CC(O)=CC3=C12)N4C3=NC5=CC(N)=CC=C54

Molecular Formula

C18H11N3O2

Molecular Weight

301.30

References & Citations

[1]Akari Yoshida, et al. Development of a novel AAK1 inhibitor via Kinobeads-based screening. Sci Rep. 2024 Mar 20;14 (1) :6723.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MUC5AC

Curated Selection

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