ALK5-IN-10
ALK5-IN-10 (Compound 5d) is a TGF-β type I receptor kinase ALK5 inhibitor, with IC50s of 0.007 and 1.98 μM for ALK5 and p38α, respectively. ALK5-IN-10 can be used for the research of cancer[1].
Product Specifications
CAS Number
1352608-94-6
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-10.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2
Molecular Formula
C22H18BrN7
Molecular Weight
460.33
References & Citations
[1]Jin C H, et al. Discovery of N- ((4- ([1, 2, 4] Triazolo [1, 5-a] Pyridin-6-Yl) -5- (6-Methylpyridin-2-Yl) -1 H-Imidazol-2-Yl) methyl) -2-Fluoroaniline (EW-7197) : a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. Journal of medicinal chemistry. 2014, 57 (10) : 4213-4238.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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