(R) -9b

(R) -9b is a potent inhibitor of ACK1 tyrosine kinase (IC50=56 nM) with anticancer activity. (R) -9b exhibits selectivity for ACK1 but has inhibitory effects on JAK family kinases JAK2 and Tyk2. (R) -9b can be used in the study of hormone-regulated cancers such as prostate and breast cancer[1].

Product Specifications

CAS Number

[1655527-68-6]

UNSPSC

12352005

Target

Ack1; JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-9b.html

Purity

99.51

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC[C@@H]4OCCC4)=N3)C=C2)CC1

Molecular Formula

C20H27ClN6O

Molecular Weight

402.92

References & Citations

[1]Lawrence H R, et al. Development of novel ACK1/TNK2 inhibitors using a fragment-based approach[J]. Journal of medicinal chemistry, 2015, 58 (6) : 2746-2763.