GSK180
GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition[1].
Product Specifications
CAS Number
[1799725-26-0]
UNSPSC
12352005
Target
KMO
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk180.html
Concentration
10mM
Purity
98.34
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CCN1C(OC2=CC(Cl)=C(Cl)C=C12)=O
Molecular Formula
C10H7Cl2NO4
Molecular Weight
276.07
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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