GSK180

GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition[1].

Product Specifications

CAS Number

[1799725-26-0]

UNSPSC

12352005

Target

KMO

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gsk180.html

Concentration

10mM

Purity

98.34

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)CCN1C(OC2=CC(Cl)=C(Cl)C=C12)=O

Molecular Formula

C10H7Cl2NO4

Molecular Weight

276.07

References & Citations

[1]Mole DJ, et al. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat Med. 2016 Feb;22 (2) :202-9.