CYM50308
CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM[1].
Product Specifications
CAS Number
1345858-76-5
Product Name Alternative
ML248
UNSPSC
12352005
Hazard Statement
H317, H319
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cym50308.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C)/C(S/C1=C\C2=C(C)N(C3=CC=C(F)C=C3F)C(C)=C2)=N/CCOC
Molecular Formula
C20H21F2N3O2S
Molecular Weight
405.46
Precautions
H317, H319
References & Citations
[1]Urbano M, et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z) -5- ((pyrrol-3-yl) methylene) -3-alkyl-2- (alkylimino) thiazolidin-4-one chemotype. Bioorg Med Chem Lett. 2011 Nov 15;21 (22) :6739-45.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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