CYM50308

CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM[1].

Product Specifications

CAS Number

[1345858-76-5]

Product Name Alternative

ML248

UNSPSC

12352005

Hazard Statement

H317, H319

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cym50308.html

Purity

98.0

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(C)/C(S/C1=C\C2=C(C)N(C3=CC=C(F)C=C3F)C(C)=C2)=N/CCOC

Molecular Formula

C20H21F2N3O2S

Molecular Weight

405.46

Precautions

H317, H319

References & Citations

[1]Urbano M, et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z) -5- ((pyrrol-3-yl) methylene) -3-alkyl-2- (alkylimino) thiazolidin-4-one chemotype. Bioorg Med Chem Lett. 2011 Nov 15;21 (22) :6739-45.