KRAS inhibitor-39
KRAS inhibitor-39 (Example 46) is an intermediate of BI-0474 (HY-148278) . BI-0474 is a robust KRASG12C inhibitor[1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-inhibitor-39.html
Purity
98.36
Smiles
N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(N5[C@@H](C)CN(C)CC5)=CC(N6CCNCC6)=C4)=NO3)CCC2
Molecular Formula
C27H35N9OS
Molecular Weight
533.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Bröker, et al. Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor. Journal of medicinal chemistry. 2022, 65 (21) :14614-14629.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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