Acivicin (hydrochloride)

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

Product Specifications

CAS Number

[161922-40-3]

Product Name Alternative

AT-125 (hydrochloride) ; U-42126 (hydrochloride)

UNSPSC

12352005

Target

Parasite; γ-Glutamyl Transferase (GGT)

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/acivicin-hydrochloride.html

Concentration

10mM

Purity

99.12

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H]Cl.ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1

Molecular Formula

C5H8Cl2N2O3

Molecular Weight

215.03

References & Citations

[1]Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30 (3) :154-60.|[2]Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6 (1) :237-245. Epub 2014 Sep 26.|[3]Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49 (7) :941-5.