Acivicin (hydrochloride)
Product Specifications
UNSPSC Description
Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
Target Antigen
Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/acivicin-hydrochloride.html
Purity
99.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H]Cl.ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1
Molecular Weight
215.03
References & Citations
[1]Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30(3):154-60.|[2]Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26.|[3]Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W016586A/Acivicin-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W016586A/Acivicin-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
161922-40-3
Available Sizes
Curated Selection
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