DOTA-tri (t-butyl ester)

DOTA-tri (t-butyl ester) belongs to the DOTA class of chelating agents. DOTA-tri (t-butyl ester) is a key raw material for synthesizing nanospherical magnetic resonance imaging (MRI) contrast agents, which are used in MR angiography and tumor angiogenesis imaging[1][2].

Product Specifications

CAS Number

[137076-54-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Radionuclide-Drug Conjugates (RDCs)

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Others; Cancer

Assay Protocol

https://www.medchemexpress.com/dota-tri-t-butyl-ester.html

Purity

99.10

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)(OC(CN1CCN(CC(O)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC1)=O)C

Molecular Formula

C28H52N4O8

Molecular Weight

572.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Kaneshiro TL, et, al. Synthesis and evaluation of globular Gd-DOTA-monoamide conjugates with precisely controlled nanosizes for magnetic resonance angiography. Biomacromolecules. 2008 Oct;9 (10) :2742-8.|[2]Sosabowski JK, et al. Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes. Nat Protoc. 2006;1 (2) :972-6.