KL201
KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues[1].
Product Specifications
CAS Number
[302939-48-6]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Cryptochrome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/kl201.html
Purity
98.18
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(C2=C(CCCC2)S3)C3=NC=N1)C4=CC=CC=C4Br
Molecular Formula
C17H14BrN3OS
Molecular Weight
388.28
Precautions
H315, H319, H320
References & Citations
[1]Simon Miller, et al. An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol. 2020 Sep 17;27 (9) :1192-1198.e5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CRY2
Available Sizes
Curated Selection
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