Amphiregulin (Human, Recombinant)

<strong>Amphiregulin (Human, Recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2010292_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Amphiregulin (Human, Recombinant) expressed in HEK 293. This protein acts as an EGF receptor (EGFR) ligand that is important for the epithelial development in various organs._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuAmphiregulin; AR; AREG; Colorectum cell-derived growth factor; CRDGF_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Morimoto Y, Hirahara K, Kiuchi M, Wada T, Ichikawa T, Kanno T, Okano M,_x000D_ Kokubo K, Onodera A, Sakurai D, Okamoto Y, Nakayama T. Amphiregulin-Producing_x000D_ Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin_x000D_ and Facilitate Airway Fibrosis. Immunity. 2018 Jul 17;49(1):134-150.e6._x000D_ _x000D_ 2: Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N,_x000D_ Husovsky C, Muir A, Giampazolias E, Dobie R, Maizels RM, Kendall TJ, Griggs DW,_x000D_ Kopf M, Henderson NC, Zaiss DM. A Macrophage-Pericyte Axis Directs Tissue_x000D_ Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation._x000D_ Immunity. 2019 Mar 19;50(3):645-654.e6._x000D_ _x000D_ 3: Wang H, Cai H, Wang X, Zhang M, Liu B, Chen Z, Yang T, Fang J, Zhang Y, Liu_x000D_ W, Han J, Guo Q, Zhang H, Wang H, Xia G, Wang C. HDAC3 maintains oocyte meiosis_x000D_ arrest by repressing amphiregulin expression before the LH surge. Nat Commun._x000D_ 2019 Dec 16;10(1):5719._x000D_ _x000D_ 4: Kefaloyianni E, Keerthi Raja MR, Schumacher J, Muthu ML, Krishnadoss V,_x000D_ Waikar SS, Herrlich A. Proximal Tubule-Derived Amphiregulin Amplifies and_x000D_ Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis. J Am Soc_x000D_ Nephrol. 2019 Dec;30(12):2370-2383._x000D_ _x000D_ 5: Dong L, Shi XH, Kang YK, Wei WB, Wang YX, Xu XL, Gao F, Yuan LH, Zhen J,_x000D_ Jiang WJ, Jonas JB. Amphiregulin and ocular axial length. Acta Ophthalmol. 2019_x000D_ May;97(3):e460-e470._x000D_ _x000D_ 6: Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin_x000D_ YE, Coppé JP, Lam EW, Campisi J, Sun Y. Targeting amphiregulin (AREG) derived_x000D_ from senescent stromal cells diminishes cancer resistance and averts programmed_x000D_ cell death 1 ligand (PD-L1)-mediated immunosuppression. Aging Cell. 2019_x000D_ Dec;18(6):e13027._x000D_ _x000D_ 7: Koeppen M, Lee JW, Seo SW, Brodsky KS, Kreth S, Yang IV, Buttrick PM, Eckle_x000D_ T, Eltzschig HK. Hypoxia-inducible factor 2-alpha-dependent induction of_x000D_ amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun. 2018_x000D_ Feb 26;9(1):816._x000D_ _x000D_ 8: Arai S, Takeuchi S, Fukuda K, Taniguchi H, Nishiyama A, Tanimoto A, Satouchi_x000D_ M, Yamashita K, Ohtsubo K, Nanjo S, Kumagai T, Katayama R, Nishio M, Zheng MM,_x000D_ Wu YL, Nishihara H, Yamamoto T, Nakada M, Yano S. Osimertinib Overcomes_x000D_ Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis_x000D_ Model of ALK-Rearranged Lung Cancer. J Thorac Oncol. 2020 May;15(5):752-765._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/30621731/">9: Raimondo S, Saieva L, Vicario E, Pucci M, Toscani D, Manno M, Raccosta S,_x000D_ Giuliani N, Alessandro R. Multiple myeloma-derived exosomes are enriched of_x000D_ amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone_x000D_ microenvironment leading to osteoclastogenesis. J Hematol Oncol. 2019 Jan_x000D_ 8;12(1):2. </a>_x000D_ _x000D_ <strong>Products Related to Amphiregulin (Human, Recombinant) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>