T3Inh-1

T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 μM) . T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream) [1].

Product Specifications

CAS Number

[50440-30-7]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/t3inh-1.html

Purity

99.93

Solubility

DMSO : 10 mg/mL (ultrasonic; adjust pH to 6 with HCl)

Smiles

O=C(NC1=CC=C(NC2=CC=NC=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=C([N+]([O-])=O)C=C45)C=C3

Molecular Formula

C27H20N6O3

Molecular Weight

476.49

References & Citations

[1]Song L, et al. Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels. Elife. 2017;6:e24051. Published 2017 Mar 31.