Siegeskaurolic acid
Siegeskaurolic acid is an orally active anti-inflammatory agent. Siegeskaurolic acid inhibits the productions of nitric oxide (NO), prostaglandin E (2) (PGE (2) ), tumor necrosis factor-alpha (TNF-alpha) and the activationon of nuclear factor-kappaB [1].
Product Specifications
CAS Number
52645-97-3
UNSPSC
12352211
Target
NF-κB; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/siegeskaurolic-acid.html
Smiles
C[C@]1(CCC2)[C@@]3([H])[C@@](C[C@H]4CO)(CC[C@]1([H])[C@]2(C)C(O)=O)C[C@H]4CC3
Molecular Formula
C20H32O3
Molecular Weight
320.47
References & Citations
[1]Park HJ, et al. Anti-inflammatory activities of ent-16alphaH,17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation. Eur J Pharmacol. 2007;558 (1-3) :185-193.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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