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Alverine

Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.

Product Specifications

CAS Number

[150-59-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/alverine.html

Smiles

CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2

Molecular Formula

C20H27N

Molecular Weight

281.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53 (10) : p. 1419-26.|[2]Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152 (8) : p. 1228-38.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

5-HT1 Receptor

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