TAT-cyclo-CLLFVY (TFA)
TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY TFA disrupts HIF-1α/HIF-1β protein-protein interaction with an IC50 of 1.3 μM[1].
Product Specifications
UNSPSC
12352209
Target
HIF/HIF Prolyl-Hydroxylase
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tat-cyclo-cllfvy-tfa.html
Solubility
H2O
Smiles
[CGRKKRRQRRRPPQ.cyclo(CLLFVY)(Disulfidebridge:Cys1-Cys1')(TFAsalt)]
Molecular Formula
C111H188N42O24S2.xC2HF3O2
Molecular Weight
2559.08 (free acid)
References & Citations
[1]Elena Miranda, et al. A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013 Jul 17;135 (28) :10418-25.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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