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TAT-cyclo-CLLFVY (TFA)

TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY TFA disrupts HIF-1α/HIF-1β protein-protein interaction with an IC50 of 1.3 μM[1].

Product Specifications

UNSPSC

12352209

Target

HIF/HIF Prolyl-Hydroxylase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tat-cyclo-cllfvy-tfa.html

Solubility

H2O

Smiles

[CGRKKRRQRRRPPQ.cyclo(CLLFVY)(Disulfidebridge:Cys1-Cys1')(TFAsalt)]

Molecular Formula

C111H188N42O24S2.xC2HF3O2

Molecular Weight

2559.08 (free acid)

References & Citations

[1]Elena Miranda, et al. A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013 Jul 17;135 (28) :10418-25.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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