Human GPR75 Full Length Protein, Flag, His Tag (Detergent)
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Product Specifications
Background
Specifications
This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 78.4 kDa.
Accession Number
O95800
Expression Region
Met 1 - Val 540
Host
HEK293
Target
GPR75
Conjugation
Unconjugated
Tag
N-Flag & C-10xHis
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Additives
Glycerol
Molecular Weight
78.4 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
100ug*1
Host or Source
HEK293
Species
Human
Protein ID
O95800
Preservative
Glycerol
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