Ro4491533
Product Specifications
UNSPSC Description
Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro4491533.html
Smiles
O=C1NC2=CC(C(F)(F)F)=C(C=C2N=C(C1)C3=CC=CC(C4=CC(C)=NC(C)=C4)=C3)C
Molecular Weight
423.43
References & Citations
[1]Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118285/Ro4491533-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118285/
Clinical Information
No Development Reported
CAS Number
579482-31-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7198158 Inquire
Rabbit anti-Oryza sativa subsp. japonica (Rice) Os01g0367900 Polyclonal Antibody
Ask
View Details 
