Dehydrocurdione

Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO) -1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[38230-32-9]

UNSPSC

12352211

Target

Keap1-Nrf2; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dehydrocurdione.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=C(CC1=O)/C(C/C(C)=C/CC[C@@H]1C)=O

Molecular Formula

C15H22O2

Molecular Weight

234.33

References & Citations

[1]Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32 (5) :892-897.|[2]Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47 (12) :476-481.