What is the catalog number for GW7845?

The catalog number for GW7845 is HY-121746.

What sizes are available for GW7845?

GW7845 is available in the following size(s): 1 Each.

GW7845 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GW7845?

GW7845 is manufactured by QuantiMol.

What is the estimated delivery time for GW7845?

Estimated delivery time for GW7845 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for GW7845?

The safety data sheet for GW7845 is available here: http://file.medchemexpress.com/batch_PDF/HY-121746/.

GW7845

GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2].

Product Specifications

CAS Number

196809-22-0

UNSPSC

12352005

Target

Apoptosis; Calcium Channel; PPAR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gw7845.html

Smiles

O=C([C@H](CC1=CC=C(C=C1)OCCC2=C(OC(C3=CC=CC=C3)=N2)C)NC4=CC=CC=C4C(OC)=O)O

Molecular Formula

C29H28N2O6

Molecular Weight

500.54

References & Citations

[1]Thomas J Heppner, et al. Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology. 2005 Jan;73 (1) :15-22. |[2]Jennifer J Schlezinger, et al. An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells. Toxicol Sci. 2007 Jul;98 (1) :125-36.|[3]N Suh, et al. A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Res. 1999 Nov 15;59 (22) :5671-3.