GW7845

GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2].

Product Specifications

CAS Number

[196809-22-0]

UNSPSC

12352005

Target

Apoptosis; Calcium Channel; PPAR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gw7845.html

Smiles

O=C([C@H](CC1=CC=C(C=C1)OCCC2=C(OC(C3=CC=CC=C3)=N2)C)NC4=CC=CC=C4C(OC)=O)O

Molecular Formula

C29H28N2O6

Molecular Weight

500.54

References & Citations

[1]Thomas J Heppner, et al. Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology. 2005 Jan;73 (1) :15-22. |[2]Jennifer J Schlezinger, et al. An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells. Toxicol Sci. 2007 Jul;98 (1) :125-36.|[3]N Suh, et al. A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Res. 1999 Nov 15;59 (22) :5671-3.