MeIm

MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM) . MeIm can be used in the study of cardiovascular diseases[1][2].

Product Specifications

CAS Number

[2043947-71-1]

UNSPSC

12352005

Target

LDLR; PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/meim.html

Smiles

CN1C(C2=CC=CC=C2)=CN=C1C3=CN=C(C4=CN=C(C5=CN=CN5C)N4C)N3C

Molecular Formula

C22H22N8

Molecular Weight

398.46

References & Citations

[1]Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) : from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024) : 13.|[2]Stucchi, et al. "Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic." Organic & Biomolecular Chemistry 14.41 (2016) : 9736-9740.