MeIm
MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM) . MeIm can be used in the study of cardiovascular diseases[1][2].
Product Specifications
CAS Number
2043947-71-1
UNSPSC
12352005
Target
LDLR; PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/meim.html
Smiles
CN1C(C2=CC=CC=C2)=CN=C1C3=CN=C(C4=CN=C(C5=CN=CN5C)N4C)N3C
Molecular Formula
C22H22N8
Molecular Weight
398.46
References & Citations
[1]Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) : from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024) : 13.|[2]Stucchi, et al. "Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic." Organic & Biomolecular Chemistry 14.41 (2016) : 9736-9740.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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