NS 1738
NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments) .
Product Specifications
CAS Number
[501684-93-1]
Product Name Alternative
NSC 213859
UNSPSC
12352005
Hazard Statement
H319
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/NS_1738.html
Purity
99.32
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)NC2=CC(Cl)=CC=C2O
Molecular Formula
C14H9Cl2F3N2O2
Molecular Weight
365.13
Precautions
H319
References & Citations
[1]Timmermann DB, et al. An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther. 2007 Oct;323 (1) :294-307.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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