3,3'-Diiodo-L-thyronine

3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].

Product Specifications

CAS Number

[4604-41-5]

Product Name Alternative

3,3'-T2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; Endogenous Metabolite

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-3-diiodo-l-thyronine.html

Purity

98.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@@H](CC1=CC=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)C(O)=O

Molecular Formula

C15H13I2NO4

Molecular Weight

525.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne) . 2019 Feb 19;10:88.|[2]Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99 (1) :89-94.|[3]Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32 (6) :e4185.