3,3'-Diiodo-L-thyronine
3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].
Product Specifications
CAS Number
4604-41-5
Product Name Alternative
3,3'-T2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Endogenous Metabolite
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/3-3-diiodo-l-thyronine.html
Purity
98.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N[C@@H](CC1=CC=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)C(O)=O
Molecular Formula
C15H13I2NO4
Molecular Weight
525.08
Precautions
H302, H315, H319, H335
References & Citations
[1]Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne) . 2019 Feb 19;10:88.|[2]Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99 (1) :89-94.|[3]Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32 (6) :e4185.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX; Human Endogenous Metabolite
Available Sizes
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