Bevonescein

Bevonescein (ALM-488) is a novel, intravenously-administrated fluorescein-conjugated peptide that binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves[1][2].

Product Specifications

CAS Number

[2276787-79-0]

Product Name Alternative

ALM-488

UNSPSC

12352209

Target

Fluorescent Dye

Type

Peptides

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/bevonescein.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1OC2(C3=CC=C(O)C=C3OC4=CC(O)=CC=C42)C5=CC=C(C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N6[C@@H](CCC6)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N7[C@@H](CCC7)C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=C(C=C8)O)=O)CC9=CC=C(C=C9)O)=O)=O)=O)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)=O)=O)=O)C=C51

Molecular Formula

C112H144N22O32

Molecular Weight

2310.47

References & Citations

[1]Kayva L Crawford, et al. Identification of Degenerated Murine Facial Nerves With Fluorescence Labeling After Transection Injury. Otolaryngol Head Neck Surg. 2023 Aug;169 (2) :234-242.|[2]Feredun Azari, et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26 (5) :050901. Feredun Azari, et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26 (5) :050901.