Dnmt2 Recombinant Rabbit Monoclonal Antibody [PSH03-43]
Selected Variant
HA721988
Size: 100 µL
tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the TRDMT1 gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms. It has been shown that human DNMT2 does not methylate DNA but instead methylates cytosine 38 in the anticodon loop of aspartic acid transfer RNA (tRNA (Asp)).
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
TRDMT1, DNMT2
Swiss Prot
O14717 Human
Cellular Locus
Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Monkey
Immunogen
Recombinant protein within human Dnmt2 aa 1-391 / 391.
Isotype
IgG
Clone
PSH03-43
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
MDA-MB-231 cell lysate, HeLa cell lysate, 293T cell lysate, HCT 116 cell lysate, U-2 OS cell lysate, COS-1 cell lysate, MCF7, human testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:2,000 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 45 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Price
Frequently Asked Questions
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