HDAC6-IN-36
HDAC6-IN-36 (compound 11d) is an inhibitor of HDAC6 with IC50 value of 8.64 nM. HDAC6-IN-36 induces neurite outgrowth of PC12 cells without producing toxic effects.
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hdac6-in-36.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=C(C(NO)=O)C=C1)[C@H](C2)N(CC3CC3)[C@H](C4=CC=C(Cl)C=C4)C5=C2C6=CC=CC=C6N5
Molecular Formula
C30H29ClN4O3
Molecular Weight
529.03
References & Citations
[1]Wen Wen , et al. Re-exploration of tetrahydro-β-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities. Bioorg Med Chem Lett. 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6
Frequently Asked Questions
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