Procaine (hydrochloride)

Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action[1][2].

Product Specifications

CAS Number

[51-05-8]

UNSPSC

12352005

Hazard Statement

H301, H317

Target

Bacterial; DNA/RNA Synthesis; Histone Demethylase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/procaine-hydrochloride.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O=C(OCCN(CC)CC)C1=CC=C(N)C=C1.Cl

Molecular Formula

C13H21ClN2O2

Molecular Weight

272.78

Precautions

H301, H317

References & Citations

[1]Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology, 1994. 33 (12) : p. 1573-9.|[2]Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res, 2003. 63 (16) : p. 4984-9.|[3]Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry, 1987. 11 (4) : p. 345-64.