SKF 81297
SKF 81297 is a potent and selective dopamine D1 receptor agonist[1].
Product Specifications
CAS Number
[71636-61-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/skf-81297.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1Cl
Molecular Formula
C16H16ClNO2
Molecular Weight
289.76
Precautions
H315, H319, H335
References & Citations
[1]Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235 (1) :143-7.|[2]Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor
Available Sizes
Curated Selection
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