SKF 81297

SKF 81297 is a potent and selective dopamine D1 receptor agonist[1].

Product Specifications

CAS Number

[71636-61-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/skf-81297.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1Cl

Molecular Formula

C16H16ClNO2

Molecular Weight

289.76

Precautions

H315, H319, H335

References & Citations

[1]Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235 (1) :143-7.|[2]Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844.