Sp-5,6-DCl-cBIMPS (sodium)

Sp-5,6-DCl-cBIMPS sodium is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS sodium stimulates insulin release. Sp-5,6-DCl-cBIMPS sodium inhibits U-46619 (HY-108566) -induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].

Product Specifications

CAS Number

[142439-96-1]

Product Name Alternative

Sp-5,6-DCI-cBIMPS

UNSPSC

12352005

Target

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sp-5-6-dcl-cbimps-sodium.html

Smiles

O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@]2(S[Na])=O)([H])N(C=NC3=C4)C3=CC(Cl)=C4Cl

Molecular Formula

C12H10Cl2N2NaO5PS

Molecular Weight

419.15

References & Citations

[1]Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 (Pt 2) (Pt 2) :521-7.|[2]Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19 (2-3) :113-22.|[3]Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276 (51) :47906-13.